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mcl 1 inhibitor  (MedChemExpress)


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    MedChemExpress mcl 1 inhibitor
    Mcl 1 Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mcl 1 inhibitor/product/MedChemExpress
    Average 94 stars, based on 4 article reviews
    mcl 1 inhibitor - by Bioz Stars, 2026-03
    94/100 stars

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    WT mice were pretreated with the Mcl-1 inhibitor, S63845 and sacrificed 16 h after the ischemic insult. A – D S63845 treatment led to decreases in numbers of kidney neutrophils but increases in neutrophil apoptosis evaluated with flow cytometry analysis of cleaved caspase 3 ( n = 4) ( A ) and cleaved caspase-9 and S100A9 co-staining (4 and 5) ( B ), in association with less injury, indicated by lower BUN ( n = 6 and 7) ( C ) and a lower tubular injury score ( n = 7 and 8) ( D ). E Mcl-1 inhibition with S63845 led to increased ex vivo bone marrow neutrophil apoptosis determined by cleaved caspase-3 flow cytometric analysis ( n = 4). Of note, cleaved caspase-3 neutrophil counts vs. total neutrophil counts are presented in parenthesis. Scale bar: 50 μm for ( B ) and 100 μm for ( D ). Data are means ± SEM, * P < 0.05, ** P < 0.01, analyzed using 2 tailed Student’s t test for ( A – D ); 2-way ANOVA followed by Tukey’s post hoc test for ( E ).

    Journal: Nature Communications

    Article Title: Myeloid EGFR deficiency accelerates recovery from AKI via macrophage efferocytosis and neutrophil apoptosis

    doi: 10.1038/s41467-025-59393-y

    Figure Lengend Snippet: WT mice were pretreated with the Mcl-1 inhibitor, S63845 and sacrificed 16 h after the ischemic insult. A – D S63845 treatment led to decreases in numbers of kidney neutrophils but increases in neutrophil apoptosis evaluated with flow cytometry analysis of cleaved caspase 3 ( n = 4) ( A ) and cleaved caspase-9 and S100A9 co-staining (4 and 5) ( B ), in association with less injury, indicated by lower BUN ( n = 6 and 7) ( C ) and a lower tubular injury score ( n = 7 and 8) ( D ). E Mcl-1 inhibition with S63845 led to increased ex vivo bone marrow neutrophil apoptosis determined by cleaved caspase-3 flow cytometric analysis ( n = 4). Of note, cleaved caspase-3 neutrophil counts vs. total neutrophil counts are presented in parenthesis. Scale bar: 50 μm for ( B ) and 100 μm for ( D ). Data are means ± SEM, * P < 0.05, ** P < 0.01, analyzed using 2 tailed Student’s t test for ( A – D ); 2-way ANOVA followed by Tukey’s post hoc test for ( E ).

    Article Snippet: The Mcl-1 inhibitor S63845 (MedChemExpress) was formulated and protected from light in 2% Vitamin E/TPGS (Sigma) in NaCl 0.9% (w/v) and was delivered to wild-type C57BL/6 mice by retro-orbital injection for 2 days prior to, and on the day of surgery for acute experiments.

    Techniques: Flow Cytometry, Staining, Inhibition, Ex Vivo

    A Male C57BL/6 (8 weeks old) mice underwent ischemic injury (renal pedicle clamping, 35 min, both kidneys, Bi-IRI)), and the Mcl-1 inhibitor ( S63845 ) was given 6 h later and daily for the next 5 days via intravenous injection at a dose of 5 mg/kg. The mice were sacrificed 3 weeks later. Mcl-1 inhibition accelerated functional recovery, indicated by: B rapid BUN decline ( n = 9 and 10), C preserved GFR ( n = 8) and attenuation of the development of kidney fibrosis, indicated by: D lower mRNA levels ( n = 6 and 9) and E protein levels ( n = 7) of profibrotic and fibrotic components as well as F quantitative Picrosirius red staining ( n = 6) ( F ). Scale bar=100 μm. Data are means ± SEM, * P < 0.05, ** P < 0.01, *** P < 0.001, analyzed using 2 tailed Student’s t test for all.

    Journal: Nature Communications

    Article Title: Myeloid EGFR deficiency accelerates recovery from AKI via macrophage efferocytosis and neutrophil apoptosis

    doi: 10.1038/s41467-025-59393-y

    Figure Lengend Snippet: A Male C57BL/6 (8 weeks old) mice underwent ischemic injury (renal pedicle clamping, 35 min, both kidneys, Bi-IRI)), and the Mcl-1 inhibitor ( S63845 ) was given 6 h later and daily for the next 5 days via intravenous injection at a dose of 5 mg/kg. The mice were sacrificed 3 weeks later. Mcl-1 inhibition accelerated functional recovery, indicated by: B rapid BUN decline ( n = 9 and 10), C preserved GFR ( n = 8) and attenuation of the development of kidney fibrosis, indicated by: D lower mRNA levels ( n = 6 and 9) and E protein levels ( n = 7) of profibrotic and fibrotic components as well as F quantitative Picrosirius red staining ( n = 6) ( F ). Scale bar=100 μm. Data are means ± SEM, * P < 0.05, ** P < 0.01, *** P < 0.001, analyzed using 2 tailed Student’s t test for all.

    Article Snippet: The Mcl-1 inhibitor S63845 (MedChemExpress) was formulated and protected from light in 2% Vitamin E/TPGS (Sigma) in NaCl 0.9% (w/v) and was delivered to wild-type C57BL/6 mice by retro-orbital injection for 2 days prior to, and on the day of surgery for acute experiments.

    Techniques: Injection, Inhibition, Functional Assay, Staining